glutenfreewaffles:

remember when you put your glasses on for the first time and you realized you could see leaves on trees

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neurosciencestuff:

Researchers discover fever’s origin

Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Researchers at Linköping University can now see precisely where these substances are produced – a discovery that paves the way for smarter drugs.

When you take an aspirin, all production of prostaglandins in the body is suppressed. All symptoms of inflammation are eased simultaneously, including fever, pain and loss of appetite. But it might not always be desirable to get rid of all symptoms – there is a reason why they appear.

”Perhaps you want to inhibit loss of appetite but retain fever. In the case of serious infections, fever can be a good thing,” says David Engblom, senior lecturer in neurobiology at Linköping University.

Eleven years ago he had his first breakthrough as a researcher when he uncovered the mechanism behind the formation of prostaglandin Eduring fever. These signaling molecules cannot pass the blood-brain barrier, the purpose of which is to protect the brain from hazardous substances. Engblom showed that instead, they could be synthesised from two enzymes in the blood vessels on the inside of the brain, before moving to the hypothalamus, where the body’s thermostat is located.

Previous work from the research team described a very simple mechanism, but there was not yet proof that it was important in real life. The study to be published in The Journal of Neuroscience with David Engblom and his doctoral student Daniel Wilhelms as lead authors is based on tests with mice that lack the enzymes COX-2 and mPGES-1 in the brain’s blood vessels. When they were infected with bacterial toxins the fever did not appear, while other signs of inflammation were not affected.

”This shows that those prostaglandins which cause fever are formed in the blood-brain barrier – nowhere else. Now it will be interesting to investigate the other inflammation symptoms. Knowledge of this type can be useful when developing drugs that ease certain symptoms, but not all of them,” explains David Engblom.

For many years there has been debate as to where the fever signaling originates. Three alternative ideas have been proposed. Firstly, that it comes from prostaglandins circulating in the blood, secondly that it comes from immune cells in the brain, and thirdly Engblom’s theory, which stresses the importance of the brain’s blood vessels. The third proposal can now be considered confirmed.

tiffanybozic:

This is my latest painting for my next show opening this fall at Joshua Liner Gallery in NYC. If you like this check out more here.

Sanguine 30” x 40” acrylic on maple panel, 2014

"I don’t know what’s the matter with me, why I’m so adept at distance, why I feel so remote from things, why life feels like a rumor."
— David Shields, How Literature Saved My Life (via larmoyante)

visualizingmath:

ted:

What do leopard spots, striped marine angelfish, and sand dune ripples have in common? Their patterns are self-organizing Turing systems! Discovered by Alan Turing in the 1950s, these repeating natural patterns can be created by the interaction of two things that spread at different speeds, one faster than the other.

I knew that name was familiar! Alan Turing is quite an interesting person. Wikipedia lists him as “a British mathematician, logician, cryptanalyst, philosopher, computer scientist, mathematical biologist, and marathon and ultra distance runner”! Furthermore, “Winston Churchill said that Turing made the single biggest contribution to Allied victory in the war against Nazi Germany” cracking codes! Read about him!

"Of all the things I am not very good at, living in the real world is perhaps the most outstanding."
— Bill Bryson (via larmoyante)
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Our brains evolved for an environment very different from the one we currently inhabit. As a result, we carry all kinds of biological baggage. Humans are still primed to detect threats and dangers that no longer exist—think of the cold sweat when you’re stressed about money, or the fight-or-flight response that kicks in when your boss yells at you. Our safety is not truly at risk here—there is little danger that we will starve or that violence will break out—though it certainly feels that way sometimes.

We have a choice about how we respond to this situation (or any situation, for that matter). We can be blindly led by these primal feelings or we can understand them and learn to filter them. Discipline in perception lets you clearly see the advantage and the proper course of action in every situation—without the pestilence of panic or fear.

"
— Ryan Holiday, The Obstacle is the Way: The Timeless Art of Turning Trials into Triumph (via ludimagister)

yzma:

janemba:

i really cannot stop laughing

RIP!!!!!!!

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USB Condom: charge your devices without allowing sneaky data-transfers

mostlysignssomeportents:

image

Those public USB charging points are tempting, but could be used to propagate all kind of grotesque malware (imagine what happens when your phone’s camera, mic, storage, keyboard and GPS start leaking your data to voyeurs and identity thieves) — sure, you can always buy a charge-only cable, but these crowdfunded adapters turn any cable into a power-only source.

Read more…

reasons-known:

ifimeanalottoyou:

Drugs Under The Microscope

In the name of Science!!!